Humans and fruitflies those pesky little buggers that are irresistibly attracted to overripe fruit share more than a sweet tooth. Both rely on the same insulin regulated molecular pathway to maintain their energy balance when starved for food,
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"Basic biological processes are remarkably well conserved through evolution,
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But it’s not simply a case of "more of the same,
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Small and easy to breed, Drosophila melanogaster is probably the most studied organism in biological research. And although they lack a pancreas,
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After a meal, the cells release insulin into the circulatory system,
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In earlier mouse studies, Montminy discovered a metabolic switch,
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To understand TORCs role in fly metabolism,
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Without functional TORC,
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Websites For Pre Order White Metallic 5s Wholesale Online Shop, although their glycogen and lipid stores were not fully replenished. "We can now use TORC as a starting point to understand the underlying mechanisms of diabetes by carrying out genetic screen. That is the beauty of the fly system."
After it had become clear that fasting put TORC to work in the nucleus, the researchers wondered whether refeeding recalled the activated genetic switch. In response to rising insulin levels the enzyme SIK2 tagged TORC and sent it to the cellular recycling bin. Without SIK2 to take TORC out of commission, the flies were super resistant to starvation and stress and lived 50 percent longer without food than their normal counterparts.
"Beyond its role in glucose and fat metabolism, insulin also regulates longevity in Drosophila and other organisms,
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Source: Salk Institute
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