NEW YORK A huge international effort involving more than 100 institutions and genetic tests on 200,
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It the latest mega collaboration to learn more about the intricate mechanisms that lead to cancer. And while the headway seems significant in many ways,
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One analysis suggests that among men whose family history gives them roughly a 20 percent lifetime risk for prostate cancer,
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The markers also could make a difference for women with BRCA gene mutations,
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Experts not connected with the work said it was encouraging but that more research is needed to see how useful it would be for guiding patient care. One suggested that using a gene test along with PSA testing and other factors might help determine which men have enough risk of a life threatening prostate cancer that they should get a biopsy. Many prostate cancers found early are slow growing and won be fatal,
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Easton said the prospects for a genetic test are greater for prostate and breast cancer than ovarian cancer,
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Breast cancer is the most common malignancy among women worldwide,
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The new results were released in 13 reports in Nature Genetics,
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Scientists used scans of DNA from more than 200,
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The scientists found 49 new risk markers for breast cancer plus a couple of others that modify breast cancer risk from rare mutated genes,
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A genetic test could be useful in identifying people who should get mammography or PSA testing,
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Among the new findings:

For breast cancer,
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For prostate cancer,
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Markers can also make a difference in estimates of breast cancer risk for women with the BRCA1 or BRCA2 gene mutations. Such women are rare,
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For patients like Vicki Gilbert of England,
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Gilbert,
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Gilbert said knowing more about the genetic risks of cancer should be reassuring for most patients. "There are so many decisions made for you when you go through cancer treatment that being able to decide something yourself is very important,
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Dr. Charis Eng,
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Most women who carry a BRCA gene choose intensive surveillance with both mammograms and MRI and some choose to have their breasts removed to prevent the disease,
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