Induced pluripotent stem cells (iPS cells) are truly talented multi taskers. They can reproduce almost all cell types and thus offer great hope in the fight against diseases like Alzheimer’s and Parkinson’s. However,
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A lot of hope is riding on induced pluripotent stem cells (iPS cells). Because they can be generated individually for every single person,
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However,
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A cooperative research study involving two research groups from the Max Planck Institute for Molecular Genetics in Berlin has now carried out a search for mutations in the mitochondrial genome of iPS cells. James Adjaye’s research group recently discovered that the mitochondria rejuvenate in the course of reprogramming. Working in cooperation with Bernd Timmermann’s Next Generation Sequencing research group,
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"The mitochondrial genome undergoes random reorganisation during reprogramming,
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One of the reasons why the mitochondrial genome is so vulnerable to mutations is that mitochondria do not have the ingenious molecular repair mechanisms found in the cell nucleus at their disposal. In addition,
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For their study,
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Human Induced Pluripotent Stem Cells Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations while Maintaining Human Embryonic Stem Cell Like Metabolic Reprogramming

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