Matthew Grunseth is Senior Manager, Calvin Chen is Manager, Ryan Kelly is Senior Manager, Sangeeta Bardhan Cook is Manager, George Megaw is Director and Larry Couture
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How
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Translational research is conducted primarily to advance the development of specific applications for a technology or scientific discovery. This often includes but
Nike Free Run Powerlines Ii Negro Verde Hombres Outlet Tienda Online 2014 is not limited to proof of concept studies, efficacy studies and preclinical investigational new drug application studies, all of which are submitted to the
Nike Free Run Powerlines Ii Negro Hombres Luna Con Descuento Grande y El Envío Rápido US Food and Drug Administration (FDA). Also, translational
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2013 Nike Free Run Powerlines Ejército reverdecido Hombres Bueno Guality Y Media Precio requires access to specialized resources such as good manufacturing practice (GMP) facilities, high throughput screening technologies
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2014 Nike Free Run Gimnasio Negro Verde Hombres Se Venden Con El Precio Bajo large animal laboratories. Over the past decade, an increasing number of
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Nike Free Run Powerlines arco iris púrpura Hombres Guardar Off50% -70% these types of resources, but what are the key components of efficient translational research, and how might an institution
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What’s out there?Commercializing translational research is expensive, but that expense can
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Nike Run Balanza libre 2014 mujeres del ciruelo rojo Con Descuento 56% -78% help scientists weather funding
2014 Nike Free Run Gimnasio Blanco Rojo Hombres Venta Aquí Con Alta Calidad droughts. A well equipped infrastructure with the right resources can act as a grant multiplier, maximizing the allocation and expenditure of grant dollars. For example, institutionally managed, and often subsidized, resources made available to grant funded researchers
Nike Free Run 3.0 V7 ​​púrpura Negro Mujeres Buena Calidad y El Envío Rápido typically cost a fraction of what external, for profit providers
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Nike Free Run Trainer 3.0 Negro Azul Hombres Para Baratos Pero Real Zapatos for the same resource. Thus, in theory, a grant awarded to an investigator at a properly resourced translational research institution could produce results on par with, or greater than, those derived from larger awards given to investigators at institutions lacking
2012 Nike Free Run 3 Gris Púrpura Mujeres Para Baratos Pero Real Para Hombre these capabilities.

The proper translational infrastructure can
Nike Free Run 3.0 V2 2012 Blanco Gris Mujeres Buena Calidad y El Envío Rápido also help build
Nike Free Run Powerlines Ii Men Negro Verde Cómodo y Envío Appropriate.Free stronger intellectual property portfolios around new
Nike Free Run Powerlines Ii Azul Rojo Hombres Regalo Para Usted o Su Familia technologies and allow first movers to be amply rewarded, thereby increasing the likelihood
Nike Free Run Powerlines Ii Verde Negro Hombres Versión Adecuado Para Usted of executing a license agreement with industry or attracting
Nike Run Balanza gratuito 2014 Negro Rosa Mujeres Aquí Sería Su Mejor Opción seed investors for
2012 Nike Free Run Tr Fit Negro Azul Hombres Adicional 50% De Descuento En Liquidación a startup. We conducted a survey to identify the critical components of successful translationally focused research institutions, targeting centers previously identified as having some degree of
Nike Run Balanza gratuito 2014 Mujeres Negro Rosa Con Precio Barato a
2012 Nike Free Run 2.0 Gris Pinke Azul Mujeres Outlet Store Waiting For You translational mission the National Cancer Institute’s National
Nike Free Run 4.0 azules claros mujeres negras Con Más Bajo Precio Auténtico Comprehensive Cancer Network centers
2012 Nike Free Run 3.0 Blanco Gris mujeres rojas Disfrute El Mayor Descuento and
Nike Free Run 3 Gris Verde 2012 Mujeres Proporciona Varios 50% De Descuento the US National
Nike Run Balanza gratuito 2014 Mujeres Gris Naranja Más De 60% De Descuento Institutes of Health’s CTSA centers. (The National Cancer Institute designates the Comprehensive Cancer
Nike Free Run 2 2 Center title to institutions that exhibit capabilities that bridge laboratory , clinical and population
2014 Nike Free Run Gimnasio Negro Azul Hombres Ahorre Tiempo y Dinero Ahora based research. The US National Institutes of Health’s CTSA program honors
2014 Nike Free Run Gimnasio Negro Verde Hombres Outlet Store Waiting For You collaborative translational and clinical research among research organizations that have complementary offerings.) Of the 41 Comprehensive
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Nike Free Run 3.0 V4 blancas púrpuras Mujeres Para Baratos Zapatos Auténticos and 61 CTSA designations we reached out to, we received 20 responses (Supplementary Table 1) on infrastructure, expertise and personnel.

Our study showed that all had small animal facilities as well as intellectual property
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Nike Free Run Powerlines Ii Marrón Verde Hombres Venta Con 70% De Descuento had large animal facilities
Nike Free Run Powerlines Ii Negro Hombres Luna Con Más Bajo Precio Auténtico (80%) and designated regulatory affairs staff (75%).
Nike Free Run 4.0 azules claros mujeres negras Ahorre Tiempo y Dinero Ahora Fewer than half had nonhuman primate facilities, but all had at least one type of GMP
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Nike Free Run 3.0 V5 Ext Gris Rosa Mujeres Con Precio Barato Importantly, just
2014 Nike Free Run Gimnasio Negro Blanco Hombres Versión Adecuado Para Usted 40% of responding institutions had an annual research budget in excess
Nike Free Run 3.0 V7 ​​Vino Rojo Oscuro Blanco Mujeres Con Descuento Grande of million, meaning that improvements in infrastructure might not be as expensive as you think. (Full data can be found in
2013 Nike Free Run Powerlines Negro Hombres Tenemos El Precio Bajo En Línea Supplementary
2014 Nike Free Run Gimnasio Negro Verde Hombres Ahorre Tiempo y Dinero Ahora Table 1.)

RecommendationsBased on our experience and the survey, we can offer recommendations
Nike Free Run Powerlines Ii Negro Hombres Luna Regalo Para Usted o Su Familia for the requirements of an efficient,
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2014 Nike Free Run Gimnasio Negro fluoresceína Hombres Para Zapatos Baratos and royalty streams) in addition to traditional grant funding. Such alternative revenue
2014 Nike Free Run Gimnasio Negro fluoresceína Hombres Para Barato Zapatos Para Hombre streams help
Nike Free Run Trainer 3.0 Negro Azul Hombres Cada Par De Zapatos Que Compra develop backstops against grant funding droughts and enable uninterrupted development of emerging technologies. Second, if
2012 Nike Free Run Tr Fit Negro Azul Hombres Envío Libre Con Entrega Rápida your translational
Nike Free Run 10o Aniversary azul claro púrpura Mujeres Con La Mejor Calidad resources, such as GMP facilities and
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2012 Nike Free Run 3.0 V2 Blanco Gris mujeres rojas Guardar Descuento Grande contract work; the rise
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Nike Free Run Powerlines Ii Negro Hombres Luna Ayuda Para Alojarse En Estilo companies looking for affordable, high quality services.

In general, a complete translational research institution should
2014 Nike Free Run Gimnasio Blanco Negro Hombres Versión Adecuado Para Usted address three core areas (Table 1): preclinical development, clinical development, and
Nike Free Run Powerlines Ii Negro Oro Hombres Ayuda Para Alojarse En Estilo business development and licensing. Institutions, depending on how many of these core areas they have, can then be categorized into three levels (Table 2).

Table 1:Full table

Level 1. To be considered a translationally focused research institution,
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Nike Run Balanza gratuito 2014 Negro Rosa Mujeres Venta Aquí Con Alta Calidad must have these minimal capabilities. First, an institution must be able to manufacture lead compounds (small molecules or biologics). This work can be done via outsourcing, of
Nike Free Run 3.0 V2 Negro Naranja Mujeres A Precio Más Bajo 55% De Descuento course, but contract manufacturing services for GMP products for preclinical toxicology and/or pharmacokinetic studies and phase 1 trials are often cost prohibitive. In house facilities
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Second, a Level 1 institution must be
Nike Free Run Powerlines Ii Azul Rojo Hombres Venta Hombres Running Zapatos capable of performing small animal studies (basically, rodents) on site; this provides an important efficacy checkpoint and a means of showing proof
2012 Nike Free Run 3.0 V2 Blanco Gris mujeres rojas En Venta En Su Selección of concept before additional resources and funding are expended. Proof of concept studies conducted in vivo are required at a minimum to engage a serious industry partner or investor and are also needed to justify a potential clinical trial to the FDA and show definitive efficacy.

Third, in house regulatory affairs personnel should be available to draft and file IND applications and manage the critical and often burdensome communications with the FDA. A competent in house regulatory affairs team can
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Nike Free Run 3.0 mujeres azules Garden Fresh Produce Hasta 50% De Descuento stakeholders
Nike Free Run 2 2 (inventors, institutional leadership and philanthropic givers) informed. In our survey, 75% of the institutions polled had integrated regulatory staff into their translational infrastructure as a core resource. Engaging the regulatory team early in the development of
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Even a basic translational
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Nike Run Balanza gratuito 2014 Gris Rosa Mujeres Se Venden Con El Precio Bajo dependent
Nike Free Run Powerlines Ii Azul Blanco Hombres Outlet Store Waiting For You on the resources and personnel already available to an institution: a
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Nike Free Run 2 2 existing subject recruitment are
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Adding phase 1 capabilities carries the highest barrier
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2012 Nike Free Run 3.0 Azul Plata Mujeres Sólo Compras En Nuestra Tienda De Ahora
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The final basic necessity for a Level 1
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If all of these elements are in place, you should be able to advance discoveries through phase 1 completely in house. Properly designed phase 1 studies can provide data that shed light on early efficacy in addition
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It is not practical for a Level 1,
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